James Gleason was born in New York City to William Gleason and Mina Crolius, who were both in the theatre. He was married to Lucile Gleason (born Lucile Webster), and had a son, Russell Gleason. As a young man James fought in the Spanish-American War. After the war he joined the stock company at the Liberty Theater in Oakland, California, which his parents were running. James and his wife then moved to Portland, Oregon, where they played in stock at the Baker Theater. For several years afterward they toured in road shows until James enlisted in the army during World War I. When he returned he appeared on the stage in "The Five Million." He then turned to writing, including "Is Zat So", which he produced for the NY stage. He also wrote and acted in "The Fall Guy" and "The Shannons on Broadway." Next he wrote The Broadway Melody (1929) for MGM. He collaborated, in 1930, on The Swellhead (1930), Dumbbells in Ermine (1930), What a Widow! (1930), Rain or Shine (1930) and His First Command (1929). He and his wife were then contracted to Pathe, Lucille to act, and James (or Jimmie as he was known) as a writer. Probably his most famous acting role was as Max Corkle, the manager of Joe Pendleton who was wrongly plucked from this life into the next, in the hit fantasy Here Comes Mr. Jordan (1941).
| Movie | Rules Don't Apply | Doctor Crone | 2016-11-23 |
| Movie | Awaken | Willy | 2013-04-09 |
| Movie | Stealing Roses | Marco | 2012-06-01 |
| Movie | American Dreamz | Journalist | 2006-03-04 |
| Movie | S1m0ne | Reporter | 2002-08-23 |
| Movie | Shadow of the Blair Witch | Jeff Schoene | 2000-10-22 |
| Movie | Why Do Fools Fall In Love | Stage Manager | 1998-08-28 |
| Movie | Mother | Waiter | 1996-12-25 |
| Movie | Sawbones | Coroner | 1995-07-25 |
| Movie | Revenge of the Nerds IV: Nerds in Love | 1994-05-09 | |
| Movie | Bloodlines: Murder in the Family | Controller | 1993-03-01 |
| Movie | Jason Goes to Hell: The Final Friday | Agent Abernathy | 1993-08-13 |
| Movie | Star | The Director | 1993-09-20 |
| Movie | For Richer, for Poorer | Salesman | 1992-01-01 |
| Movie | Boris and Natasha | Taxi Driver | 1992-04-17 |
| Movie | My Demon Lover | Alert Cop | 1987-04-24 |
| Movie | Hollywood My Home Town | Self (archive footage) | 1965-12-31 |
| Movie | Man or Gun | Sheriff Jim Jackson | 1958-05-30 |
| Movie | The Female Animal | Tom Maloney | 1958-01-22 |
| Movie | Rock-a-Bye Baby | Doc Simpkins | 1958-07-23 |
| Movie | The Last Hurrah | Cuke Gillen | 1958-12-31 |
| Movie | Once Upon a Horse... | Postmaster | 1958-09-01 |
| Movie | Money, Women and Guns | Henry Devers | 1958-10-01 |
| Movie | Spring Reunion | Collie | 1957-03-01 |
| Series | Leave It to Beaver | Unknown | 1957-10-04 |
| Movie | Man in the Shadow | Hank James | 1957-12-12 |
| Movie | Star in the Dust | Orval Jones | 1956-06-13 |
| Movie | The Night of the Hunter | Uncle Birdie Steptoe | 1955-07-27 |
| Movie | The Girl Rush | Ether Ferguson | 1955-09-16 |
| Movie | Screen Directors Playhouse: Rookie of the Year | Ed Shafer | 1955-12-07 |
| Series | Alfred Hitchcock Presents | Unknown | 1955-10-02 |
| Movie | Suddenly | Peter 'Pop' Benson | 1954-09-17 |
| Movie | Forever Female | Eddie Woods | 1953-11-28 |
| Movie | We're Not Married! | Duffy | 1952-07-11 |
| Movie | The Story of Will Rogers | Bert Lynn | 1952-07-17 |
| Series | Cavalcade of America | Unknown | 1952-10-01 |
| Movie | What Price Glory | General Cokely | 1952-08-22 |
| Movie | Come Fill the Cup | Charley Dolan | 1951-10-24 |
| Series | Racket Squad | Unknown | 1951-06-07 |
| Movie | I'll See You in My Dreams | Fred Townsend | 1951-12-06 |
| Movie | The Yellow Cab Man | Mickey Corkins | 1950-03-25 |
| Movie | Key to the City | Sergeant Hogan | 1950-02-02 |
| Movie | Riding High | Racing Secretary | 1950-04-12 |
| Series | The Colgate Comedy Hour | Unknown | 1950-09-10 |
| Movie | The Jackpot | Harry Summers | 1950-11-01 |
| Movie | Joe Palooka in the Squared Circle | Knobby Walsh | 1950-11-04 |
| Movie | Bad Boy | Chief | 1949-02-22 |
| Movie | Take One False Step | Captain Gledhill | 1949-08-14 |
| Movie | The Life of Riley | Gillis | 1949-04-16 |
| Movie | Smart Woman | Sam Corkle | 1948-04-30 |
| Movie | The Dude Goes West | Sam Briggs | 1948-05-30 |
| Movie | The Return of October | Uncle Willie Ramsey | 1948-10-26 |
| Movie | When My Baby Smiles at Me | Lefty Moore | 1948-11-10 |
| Movie | The Homestretch | Doc Kilborne | 1947-05-04 |
| Movie | Down to Earth | Max Corkle | 1947-08-21 |
| Movie | The Bishop's Wife | Sylvester | 1947-12-25 |
| Movie | Tycoon | Pop Mathews | 1947-12-27 |
| Movie | The Hoodlum Saint | Snarp | 1946-04-04 |
| Movie | The Well Groomed Bride | Captain Hornby | 1946-05-17 |
| Movie | Home Sweet Homicide | Sgt. O'Hare | 1946-10-02 |
| Movie | Lady Luck | Sacramento Sam | 1946-10-30 |
| Movie | This Man's Navy | Jimmy Shannon | 1945-01-04 |
| Movie | A Tree Grows in Brooklyn | McGarrity | 1945-02-28 |
| Movie | The Clock | Al Henry | 1945-05-25 |
| Movie | Captain Eddie | Tom Clark | 1945-06-18 |
| Movie | A Guy Named Joe | “Nails” Kilpatrick | 1944-02-25 |
| Movie | Once Upon a Time | Moke McGillicuddy | 1944-06-29 |
| Movie | The Keys of the Kingdom | Rev. Dr. Wilbur Fiske | 1944-12-15 |
| Movie | Arsenic and Old Lace | Lt. Rooney | 1944-09-01 |
| Movie | Crash Dive | Chief Mike 'Mac' McDonnell | 1943-04-22 |
| Movie | A Date with the Falcon | Inspector Michael 'Mike' O'Hara | 1942-01-16 |
| Movie | My Gal Sal | Pat Hawley | 1942-04-30 |
| Movie | Hay Foot | Colonel J. A. Barkley | 1942-01-02 |
| Movie | The Falcon Takes Over | Inspector Mike O'Hara | 1942-05-29 |
| Movie | Manila Calling | Tim O'Rourke | 1942-10-16 |
| Movie | Tales of Manhattan | Joe - Mission Aid Society | 1942-08-05 |
| Movie | Footlight Serenade | Bruce McKay | 1942-08-01 |
| Movie | Here Comes Mr. Jordan | Max Corkle | 1941-08-07 |
| Movie | Meet John Doe | Henry Connell | 1941-03-14 |
| Movie | Tanks a Million | Col. 'Spitfire' Barkley | 1941-09-12 |
| Movie | Affectionately Yours | 'Chet' Phillips | 1941-05-10 |
| Movie | Nine Lives Are Not Enough | Sergeant Daniels | 1941-09-20 |
| Movie | Breakdowns of 1941 | Self (archive footage) (uncredited) | 1941-11-14 |
| Movie | Babes on Broadway | Thornton Reed | 1941-12-31 |
| Movie | Grandpa Goes To Town | Joe Higgins | 1940-04-13 |
| Movie | Should Husbands Work? | Joe Higgins | 1939-07-26 |
| Movie | My Wife's Relatives | Joe Higgins | 1939-05-20 |
| Movie | On Your Toes | Phil Dolan Sr. | 1939-10-14 |
| Movie | Money To Burn | Joe Higgins | 1939-12-31 |
| Movie | The Higgins Family | Joe Higgins | 1938-03-28 |
| Movie | Screen Snapshots Series 17, No. 6 | Self | 1938-02-04 |
| Movie | Army Girl | Hennessy | 1938-08-11 |
| Movie | Cinema Circus | Himself | 1937-01-27 |
| Movie | Forty Naughty Girls | Police Insp. Oscar Piper | 1937-09-24 |
| Movie | Manhattan Merry-Go-Round | Danny The Duck | 1937-11-26 |
| Movie | Yours for the Asking | Saratoga | 1936-07-23 |
| Movie | Murder on a Bridle Path | Police Insp. Oscar Piper | 1936-04-17 |
| Movie | The Ex-Mrs. Bradford | Inspector Corrigan | 1936-04-24 |
| Movie | Don't Turn 'em Loose | Detective Daniels | 1936-09-18 |
| Movie | The Plot Thickens | Police Insp. Oscar Piper | 1936-12-11 |
| Movie | The Big Game | George Scott | 1936-10-09 |
| Movie | Murder on a Honeymoon | Police Insp. Oscar Piper | 1935-02-22 |
| Movie | West Point of the Air | Joe 'Bags' | 1935-03-23 |
| Movie | Hot Tip | Jimmy McGill | 1935-08-20 |
| Movie | We're Only Human | Detective Danny Walsh | 1935-12-27 |
| Movie | Hollywood Hobbies | Himself | 1935-07-05 |
| Movie | The Meanest Gal in Town | Duke Slater | 1934-01-12 |
| Movie | Search for Beauty | Dan Healy | 1934-02-02 |
| Movie | Murder on the Blackboard | Police Insp. Oscar Piper | 1934-06-15 |
| Movie | Change of Heart | Hot Dog Vendor (uncredited) | 1934-05-18 |
| Movie | Clear All Wires! | Lefty Williams | 1933-02-24 |
| Movie | Hoopla | Jerry | 1933-11-30 |
| Movie | High Hats and Low Brows | Danny Ruff | 1932-07-10 |
| Movie | Blondie of the Follies | Pa McClune | 1932-09-01 |
| Movie | Fast Companions | Silk Henley | 1932-06-22 |
| Movie | Lady and Gent | Pin Streaver | 1932-07-10 |
| Movie | Yoo-Hoo | Jimmy Gleason | 1932-10-04 |
| Movie | The Crooked Circle | Arthur Crimmer | 1932-09-25 |
| Movie | The Penguin Pool Murder | Police Insp. Oscar Piper | 1932-12-09 |
| Movie | The Devil Is Driving | 'Beef' Evans | 1932-12-09 |
| Movie | Beyond Victory | Jim Mobley | 1931-04-03 |
| Movie | A Free Soul | Eddie | 1931-06-02 |
| Movie | It's a Wise Child | Cool Kelly | 1931-04-10 |
| Movie | Sweepstakes | Sleepy Jones | 1931-07-10 |
| Movie | Suicide Fleet | Skeets | 1931-11-20 |
| Movie | The Big Gamble | Fred 'Squint' Dugan | 1931-09-04 |
| Movie | Puttin' on the Ritz | James 'Jimmy' Tierney | 1930-02-19 |
| Movie | Dumb-bells in Ermine | Mike | 1930-05-10 |
| Movie | The Matrimonial Bed | Gustave Corton | 1930-08-01 |
| Movie | Her Man | Steve | 1930-09-21 |
| Movie | The Broadway Melody | Music Publisher (uncredited) | 1929-02-08 |
| Movie | Oh, Yeah! | Dusty | 1929-10-19 |
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